منابع مشابه
Astrocytic LRP1 Mediates Brain Aβ Clearance and Impacts Amyloid Deposition.
Accumulation and deposition of amyloid-β (Aβ) in the brain represent an early and perhaps necessary step in the pathogenesis of Alzheimer's disease (AD). Aβ accumulation leads to the formation of Aβ aggregates, which may directly and indirectly lead to eventual neurodegeneration. While Aβ production is accelerated in many familial forms of early-onset AD, increasing evidence indicates that impa...
متن کاملAstrocytic modulation of neuronal excitability through K+ spatial buffering
The human brain contains two major cell populations, neurons and glia. While neurons are electrically excitable and capable of discharging short voltage pulses known as action potentials, glial cells are not. However, astrocytes, the prevailing subtype of glia in the cortex, are highly connected and can modulate the excitability of neurons by changing the concentration of potassium ions in the ...
متن کاملAmyloid-β1-42 slows clearance of synaptically released glutamate by mislocalizing astrocytic GLT-1.
GLT-1, the major glutamate transporter in the adult brain, is abundantly expressed in astrocytic processes enveloping synapses. By limiting glutamate escape into the surrounding neuropil, GLT-1 preserves the spatial specificity of synaptic signaling. Here we show that the amyloid-β peptide Aβ1-42 markedly prolongs the extracellular lifetime of synaptically released glutamate by reducing GLT-1 s...
متن کاملNeurobiology of Disease Enhancing Astrocytic Lysosome Biogenesis Facilitates A Clearance and Attenuates Amyloid Plaque Pathogenesis
Qingli Xiao,1 Ping Yan,1 Xiucui Ma,2,3 Haiyan Liu,2 Ronaldo Perez,1 Alec Zhu,1 Ernesto Gonzales,1 Jack M. Burchett,1 Dorothy R. Schuler,1 John R. Cirrito,1 Abhinav Diwan,2,3* and Jin-Moo Lee1* 1Department of Neurology and the Hope Center for Neurological Disorders and 2Division of Cardiology and Center for Cardiovascular Research, Washington University School of Medicine, St. Louis, Missouri 63...
متن کاملEnhancing astrocytic lysosome biogenesis facilitates Aβ clearance and attenuates amyloid plaque pathogenesis.
In sporadic Alzheimer's disease (AD), impaired Aβ removal contributes to elevated extracellular Aβ levels that drive amyloid plaque pathogenesis. Extracellular proteolysis, export across the blood-brain barrier, and cellular uptake facilitate physiologic Aβ clearance. Astrocytes can take up and degrade Aβ, but it remains unclear whether this function is insufficient in AD or can be enhanced to ...
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ژورنال
عنوان ژورنال: International Journal of Molecular Sciences
سال: 2021
ISSN: 1422-0067
DOI: 10.3390/ijms22052520